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Avodat should nv b takn by a woman a child. Dutastid can b absobd though th skin, and womn childn should not b pmittd thandl Avodat capsuls. Although this mdicin is not us by womn, this mdication can caus bith dcts i a woman is xposd tit duing pgnancy. Avodat capsuls should not b handld by a woman whis pgnant whmay bcom pgnant. I a woman accidntally coms intcontact with this mdication om a laking capsul, wash th aa with soap and wat ight away.
Pgnancy. In animal poduction and dvlopmntal toxicity studis, dutastid inhibitd dvlopmnt mal tus xtnal gnitalia. Tho, AVODAT may caus tal ham whn administd ta pgnant woman. I AVODAT is usd duing pgnancy i th patint bcoms pgnant whil taking AVODAT, th patint should b appisd th potntial hazad tth tus [s WANINGS AND PCAUTIONS , Us In Spciic Populations ]. Womn childbaing potntial [s WANINGS AND PCAUTIONS , Us In Spciic Populations ]. Pdiatic patints [s Us In Spciic Populations ]. Patints with pviously dmonstatd, clinically signiicant hypsnsitivity (.g., sious skin actions, angiodma) tAVODAT oth 5 alpha-ductas inhibitos [s ADVS ACTIONS ].
Ndos adjustmnt is ncssay AVODAT in patints with nal impaimnt [s CLINICAL PHAMACOLOGY ].
Dutastid inhibits th convsion tstoston tdihydotstoston (DHT). DHT is th andogn pimaily sponsibl th initial dvlopmnt and subsqunt nlagmnt th postat gland. Tstoston is convtd tDHT by th nzym 5 alpha-ductas, which xists as 2 isooms, typ 1 and typ 2. Th typ 2 isonzym is pimaily activ in th poductiv tissus, whil th typ 1 isonzym is alssponsibl tstoston convsion in th skin and liv.
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