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Cephalosporinsincluding Supraxmay be associated with a fall in prothrombin activityThose at risk include patients with renal or hepatic impairmentor poor nutritional stateas well as patients receiving a protracted course of antimicrobial therapyand patients previously stabilized on anticoagulant therapyProthrombin time should be monitored in patients at risk and exogenous vitamin K administered as indicated.

Thereforethe tablet or capsule should not be substituted for the chewable tablets or suspension in the treatment of otitis mediasee Clinical Pharmacology12.3

Several cephalosporins have been implicated in triggering seizuresparticularly in patients with renal impairment when the dosage was not reducedsee DOSAGE AND ADMINISTRATION and OVERDOSAGEIf seizures associated with drug therapy occurthe drug should be discontinuedAnticonvulsant therapy can be given if clinically indicated.

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suprax tablets and capsules are stored at room temperature away from moisture, heat, and light.

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